AN UNBIASED VIEW OF PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation variable eIF2α. The resulting translational arrest blocks viral replication. PKR belongs into a conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to unique stimuli12, triggering the integrated stress